Endocrine Abstracts

Epidemiological data clearly evidence a protective role of estrogens against the development of colon cancer and ERβ has been identified as the predominant ER subtype in human colon. More recently it has been identified as a favourable prognostic marker in this disease, possibly explaining the protective effect of estrogens against colon cancer development. To understand the specific role and mechanism of action of ERβ in colon tumorigenesis we developed an in vit...